Medicinal Chemistry
Taj can support your discovery
chemistry needs at its Hyderabad,
India, facility offering:
- Small focused library synthesis
to aid hit finding or hit expansion
- Assay development- preparation
of an in vitro biology assay (either biochemical or cell-based),
based on the molecular target, therapeutic area, and throughput
consideration (low-medium-high). Taj’s biologists then produce the
recombinant molecular targets and provide purification and assay
development services
- HDAC and sirtuins
- Epigenetic mrkers
- Cell cycle regulators
- Protein-protein interactions
- Screening/hit finding - a
low-to-medium throughput screening campaign is run, with necessary
hits confirmed using secondary counter screening such as ELISA
- Hit-to-lead/lead identification
– expansion of different chemical classes by synthesizing close
analogues/scaffold modifications. Possible selection of compound
classes with suitable activity profile and ADME/tox properties (in
silico/in vitro). Taj utilizes the following to aid in this
process:
- Ligand-based design
- Structural-based design
- Virtual screening
- Lead optimization – refinement
of compound class of choice including in vivo DMPK, toxicology and
scale up consideration – fulfilling IND requirements
Chemistry support may be offered
together with in vitro biology as a comprehensive “discovery
package” including synthesis of analogues, SAR studies, assay
development and in vitro screening.
Dramatically shortened timelines:
the synthesized compounds are immediately tested by Taj's biology
teams, and the results obtained drive the design and synthesis of a
new compound set.
This lead optimization can be
further expanded by integrating with early DMPK studies at Taj’s
preclinical facilities, together with preformulation and formulation
studies within our pharmaceutical sciences business. Additionally, SSCI's unprecedented expertise
in polymorph, salt screening, co-crystal selection, or amorphous
dispersions to overcome inherent solubility/dissolution issues could
potentially aid in selecting your best candidate.
India