Welcome To Taj Active Pharmaceuticals Ingredients & Chemicals (api) Taj Pharmaceuticals Limited (Manufacturers) India
    About Worldwide  |     FAQs    |    Careers    |        Media Center  |    Taj Pharmaceuticals  World   |    TAJ Group
    Taj Active Pharmaceuticals Ingredients & Chemicals (api) Taj Pharmaceuticals Limited

chemicals suppliers

      India              Latin America/ Caribbean            Africa & Middle East              Asia              Russia              Europe  

Active Pharmaceutical Ingredients  TAJ PHARMACEUTICALS LIMITED  

Home    API   Pharmaceuticals API List    Chemicals    Manufacturing     Product Development    Product Search    Agro Chemicals
  Custom Pharma Services      Contact Us

BP - British Pharmacopoeia CP - Chinese Pharmacopoeia EP - European Pharmacopoeia JP - Japanese Pharmacopoeia USP - United States Pharmacopoeia
***
Product exploitation, including development, sales and offer for sale are performed where permissible by patent law. This presentation is not and should not constitute as an offer for sale in territories where it is not permitted by law.

 

 Taj Active Pharmaceuticals Ingredients & Chemicals

   Bulk Drugs Pharmaceuticals
   Chemicals
   Oseltamivir Phosphate
   Phenyl Propanolamine
   Phenylephrine
   Etafedrine
   Theophylline
   Tramadol
   Methylphenidate
   Morphine HCl
   Morphine sulphate
   Ephedrine (EPH)
   Pseudoephedrine hydrochloride
   Codeine base
   Codeine phosphate hemihydrate
   Zolpidem Tartrate
   Caffeine
   Gabapentin
   Gemcitabine
   Glimepiride
   Granisetron Hcl
   Ibandronate Sodium
   Imatinib Mesylate
   Irbesartan
   Irinotecan Hcl
   Isradipine
   Lamotrigine
   Lercanidipine Hcl
   Letrozole
   Losartan Potassium
   Loteprednol Etabonate
   Magnesium Valproate
   Meloxicam
   Memantine Hcl
   Mesalazine
   Metamizol Magnesium
   Metaxalone
   Metformin Hcl
   Metoprolol Tartrate
   Mifepristone
   Mirtazapine
   Modafinil
   Mometasone Furoate
   Naltrexone Hcl
   Netaglinide
   Octreotide Acetate
   Olanzapine
   Ondansetron Base
   Ondansetron Hcl
   Oxaliplatin
   Oxcarbazepine
   Oxethazaine
   Pamidronate Disodium
   Pentoxifylline
   Perindopril
   Pioglitazone
   PiroxicamBetacyclodextrine
   Raloxifene Hcl
   Repaglinide
   Rivastigmine Tartrate
   Ropinirole
   Sertraline Hcl
   Sodium Valproate
   Sildenafil Citrate
   Sumatriptan Succinate
   Temozolomide
   Terlipressin
   Testosterone
   Tiagabine Hcl
   Tizanidine Hcl
   Topiramate
   Tramadol Hcl
   Valproic Acid
   Venlafaxine Hcl
   Ziprasidone Hcl
   Zoledronic Acid
   Acenocoumarol
   Aluminium-magnesium-hydroxy-carbonate-hexahydrate
   Buprenorphine HCl
   Dihydrocodeine hydrogentartrate
   Ethylmorphine HCl
   Glibornuride
   Hydroxychloroquine sulphate
   Noroxymorphone
   Noscapine base
   Oxycodone
   Oxymorphone
   Phenobarbital acid
   Phenobarbital sodium
   Thebaine
   Pharmaceuticals API
   Alfuzosin
   Amlodipine Besylate
    Aripiprazole
   Atorvastatin Calcium
   Caffeine
   Candesartan Cilaxetil
   Cefdinir
   Cetirizine Dihydrochloride
   Ciprofloxacin HCl
   Dextromethorphan Base
   Diltiazem HCl
   Domperidone Base
   Domperidone Maleate
   Doxazosin Mesylate
   Duloxetine HCl
   Dutasteride
   Enalapril Maleate
   Esomeprazole Magnesium
   Famotidine
   Fexofenadine HCl
   Fluconazole
   Fluoxetine HCl
   Galantamine HBr
   Ibuprofen
   Lacidipine
   Lamotrigine
   Lansoprazole
   Levetiracetam
   Levo Cetirizine
   Levofloxacin
   Loratadine
   Losartan Potassium
 
   

delivering world-class generics

 



Oseltamivir Phosphate ( INN)
Oseltamivir Phosphate CAS No.: 204255-11-8
Product name: Oseltamivir phosphate
Chemical name: Ethyl(3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate phosphate
CAS No.: 204255-11-8
Molecular formula : C16H28N2O4.H3PO4
Assay: 97%min



Product Description

Appearance: White to off-white crystalline powder
Purity(HPLC): 99%min
Melting Point : 201-203degree
Optical Rotation: -34.0- -38.0degree
Moisture: 0.30%max
Heavy metals: 20ppm max
Residue on ignition: 0.1%max
Impurity Ro-1637: 0.03%max
Any other individual impurity: 0.50%max
Total impurities: 1.0%max

Productivity: 500kg/month


Mode of action

CAS No.:	204255-11-8Oseltamivir is a neuraminidase inhibitor, serving as a competitive inhibitor towards sialic acid, found on the surface proteins of normal host cells. By blocking the activity of the neuraminidase, Oseltamivir prevents new viral particles from being released by infected cells.

Resistance

As with other antivirals, resistance to the agent was expected with widespread use of oseltamivir, though the emergence of resistant viruses was expected to be less frequent than with amantadine or rimantadine. The resistance rate reported during clinical trials up to July 2004 was 0.33% in adults, 4.0% in children, and 1.26% overall. Mutations conferring resistance are single amino acid residue substitutions in the neuraminidase enzyme.
H3N2
As with other antivirals, resistance to the agent was expected with widespread use of oseltamivir, though the emergence of resistant viruses was expected to be less frequent than with amantadine or rimantadine. The resistance rate reported during clinical trials up to July 2004 was 0.33% in adults, 4.0% in children, and 1.26% overall. Mutations conferring resistance are single amino acid residue substitutions in the neuraminidase enzyme.
Mutant H3N2 influenza A virus isolates resistant to oseltamivir were found in 18% of a group of 50 Japanese children treated with oseltamivir.This rate was similar to another study where resistant isolates of H1N1 influenza virus were found in 16.3% of another cohort of Japanese children. Several explanations were proposed by the authors of the studies for the higher-than-expected resistance rate detected. First, children typically have a longer infection period, giving a longer time for resistance to develop. Second, Kiso et al. claim to have used more rigorous detection techniques than previous studies.

H5N1 avian influenza

High-level resistance has been detected in one girl suffering from H5N1 avian influenza in Vietnam. She was being treated with oseltamivir at time of detection. de Jong et al. (2005) describe resistance development in two more Vietnamese patients suffering from H5N1, and compare their cases with six others. They suggest that the emergence of a resistant strain may be associated with a patient's clinical deterioration. They also note that the recommended dosage of oseltamivir does not always completely suppress viral replication, a situation that could favor the emergence of resistant strains. Moscona (2005) gives a good overview of the resistance issue, and says that personal stockpiles of Tamiflu could lead to under-dosage and thus the emergence of resistant strains of H5N1.

Resistance is of concern in the scenario of an influenza pandemic (Wong and Yuen 2005), and may be more likely to develop in avian influenza than seasonal influenza due to the potentially longer duration of infection by novel viruses. Kiso et al. suggest that "a higher prevalence of resistant viruses should be expected" during a pandemic.

Note: Veterinary use
There have been anecdotal reports of oseltamivir reducing disease severity and hospitalization time in canine parvovirus infection. The drug may limit the ability of the virus to invade the crypt cells of the small intestine and decrease gastrointestinal bacteria colonization and toxin production.


There have been anecdotal reports of oseltamivir reducing disease severity and hospitalization time in canine parvovirus infection. The drug may limit the ability of the virus to invade the crypt cells of the small intestine and decrease gastrointestinal bacteria colonization and toxin production.

 
          text logo
  PDF DOWNLOAD      WORD DOCUMENT    TEXT DOCUMENT

 

Product Enquiry Product Quotation Sample Request Place Your Order    
Product Enquiry Product Quotation Sample Request Place Your Order  
 
   Chemicals
   Ethanol
   Phenyl acetic acid
   3,4-methylenedioxyphenyl-2-propanone
   Pseudoephedrine
   Piperidine
   Methylamine
   Propionic anhydride
   Para Methoxy Phenyl Acetone
   Para Methoxy Phenyl Acetic Acid
   Raspberry Ketone
   Benzyl Acetone
   Tyramine
   Biphenyl (Phenyl benzene)
   1-phenyl-1-hexanone
   Benzene
   Benzyl methyl ketone
   Bromo phenyl acetone (1-Bromo-1-phenyl-2-propanone)
   3'-Aminoacetophenone
   3'-Chloroacetophenone
   Toluene
   Denatonium Benzoate
   Anthranilic acid
   Ephedrine
   Ergonovine
   Ergotamine
   Hydroiodic
   Norpseudoephedrine
   Phenylpropanolamine
   Phosphorus
   Benzaldehyde
   Nitroethane
   Gamma butyrolactone
   N-Phenethyl-4-piperidinone
   Methylamine
   Ethylamine
   Isosafrole
   Safrole
   Piperonal
   N-methylephedrine
   N-methylpseudoephedrine
   Acetic anhydride
   Diethyl ether
   Potassium permanganate
   2-butanone
   Toluene
   Potassium permanganate
   2-butanone
   Methyl isobutyl ketone
   Hydrochloric acid
   Para Anisyl Choride
   Para Anisic Acid
   Para Anisyl Bromide
   Para Anisoyl Acetone
   Methyl Tyramine
   Tyramine
   Para Cresyl Acetate
   Para Cresyl Methyl Ether
   Anisyl Formate
   Ortho Anisic Aldehyde
   3-Aminopropyl Imidazole
   3-Benzyloxy Propionitrile
   1-Hydroxy Cyclohexyl-4-Methoxyphenylacetonitrile
   Veratrol
   Manganese Sulphate Monohydrate
   Pharmaceuticals API
   Rabeprazole Sodium
   Ramipril
   Ranitidine Hydrochloride
   Risperidone
   Rivastigmine Tartrate
   Rizatriptan 
   Rosiglitazone Maleate
   Sevelamer hydrochloride
   Telmisartan
   Tamsulosin HCl
   Tegaserod Maleate
   Terbinafine HCl
   Testosterone
   Tolterodine Tartrate
   Trandolapril 
   Montelukast Sodium
   Moxifloxacin HCl
   Naproxen
   Naratriptan
   Norfloxacin
   Nizatidine
   Nandrolone Decanoate
   Olmesartan
    Omeprazole
   Omeprazole Sodium
   Oxaprozin
   Paroxetine
   Pantoprazole Sodium
   Primidone
   Quetiapine Fumarate
   Quinine Sulfate
   Metoprolol Succinate
   Valdecoxib
   Valsartan
   Venlafaxine
   Voriconazole
   Zolmitriptan 
   Zonisamide
   Betalactams Piperacillin
   Tazobactam
   Meropenem
   Cefalexin
   Cefradine
   Cefadroxil
   Cefprozil
   Cefixime
   Ceftibuten
   Cefditoren Pivoxil
   Cefazolin Sodium
   Cefuroxime Sodium
   Cefoxitin Sodium
   Cefotetan Sodium
   Cefotaxime Sodium
   Cefoperazone Sodium
   Ceftizoxime Sodium

 

 

Home Page Company Profile Our Products     Amlodpine Besylates     Atorvastatin Calcium     Caffeine     Clopidogrel Bisulfate     Clomipramine HCL     Losartan Potassium     Metformin Hcl     Nandrolone Decanoate     Pantoprazole Sodium     Pseudoephedrine Hydrochloride     Quinine Sulfate     Ramipril     Ranitidine Hydrochloride     Sertraline Hcl     Sevelamer Hydrochloride     Sodium Valproate     Testosterone     Theophyline     Valsartan     Toluene     Benzyl Chloride     Ethanol     Modafinil     Para Methoxy Phenyl Acetone     Anthranilic Acid

Copyright Taj Pharmaceuticals Ltd. | Privacy Policy | Terms & Conditions |
Sitemap

   
 

2004 - 2009 Taj Pharmaceuticals Limited . All rights reserved
Active Pharmaceutical Ingredients manufacturer, exporter, drug ingredients, pharmaceuticals, India
Note:-We are committed to helping you find the right answers to your questions and concerns. However, this web site is not intended to give investment advice, promote the use of Taj Pharmaceuticals  Ltd products or provide information on which to base medical treatment. If you have questions regarding any Taj Pharmaceuticals  Ltd product or are experiencing a medical emergency, please consult your health care provider.
Additionally, contact information on this web site cannot be used to report adverse drug events. If you are a physician, please follow the procedures required by your country's regulations. Please choose one of the given options to contact us and we will respond to your inquiry as quickly as possible.