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Trandolapril CAS number 87679-37-6


CAS number 87679-37-6

Formula Structure :
Trandolapril Formula C24H34N2O5
Systematic (IUPAC) name
(2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid

CAS number 87679-37-6
ATC code C09AA10
PubChem 5484727
DrugBank APRD01269

Chemical data
Formula C24H34N2O5
Mol. mass 430.537 g/mol

Pharmacokinetic data
Protein binding Trandolapril 80%
(independent of concentration)
Trandolaprilat 65 to 94%
Metabolism Hepatic
Half life 6 hours (trandolapril)
10 hours (trandolaprilat)
Excretion Fecal and renal

Trandolapril is the ethyl ester prodrug of a nonsulfhydryl angiotensin converting enzymeinhibitor, trandolaprilat. Trandolapril is chemically described as (2S, 3aR, 7aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl] hexahydro-2-indo-linecarboxylic acid, 1-ethyl ester. Its empirical formula is C24H34N2O5and M.W.= 430.54
Melting Point = 125C

Trandolapril is used alone or in combination with other medications to treat high blood pressure. It is also used to improve survival in patients with heart failure after a heart attack. Trandolapril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.
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   Phenyl acetic acid
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   Para Methoxy Phenyl Acetone
   Para Methoxy Phenyl Acetic Acid
   Raspberry Ketone
   Benzyl Acetone
   Biphenyl (Phenyl benzene)
   Benzyl methyl ketone
   Bromo phenyl acetone (1-Bromo-1-phenyl-2-propanone)
   Denatonium Benzoate
   Anthranilic acid
   Gamma butyrolactone
   Acetic anhydride
   Diethyl ether
   Potassium permanganate
   Potassium permanganate
   Methyl isobutyl ketone
   Hydrochloric acid
   Para Anisyl Choride
   Para Anisic Acid
   Para Anisyl Bromide
   Para Anisoyl Acetone
   Methyl Tyramine
   Para Cresyl Acetate
   Para Cresyl Methyl Ether
   Anisyl Formate
   Ortho Anisic Aldehyde
   3-Aminopropyl Imidazole
   3-Benzyloxy Propionitrile
   1-Hydroxy Cyclohexyl-4-Methoxyphenylacetonitrile
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