CAS number 51018-28-1
Linear Formula: C6H5CH[CH(CH3)N(CH3)2]OH
Molecular Weight: 179.26
MDL number: MFCD00064260
PubChem Substance ID: 24857422
optical activity [α]21/D +48°, c = 5 in methanol
bp 145 °C/24 mmHg(lit.)
mp 29-31 °C(lit.)
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
WGK Germany 3
Flash Point(F) 235 °F
Flash Point(C) 113 °C
Treatment of (Image )-(η6-Image ,Image -dimethylamphetamine)Cr(CO)3,
with Image -butyllithium below -40°C gives a stable benzylic carbanion
Image loss of the Image -Image -benzylic proton. Warming of this anion
above -40°C gives (η6-Image -β-methylstyrene)Cr(CO)3 Image an ElcB type
elimination whilst trapping with an electrophile below -40°C gives
benzylically functionalised amphetamines with overall retention of
The use of oxodiperoxymolybdenum(pyridine)hexamethylphosphoramide as the
electrophile gives optically pure (Image ,Image )-Image -methylpseudoephedrine
N-methylpseudoephedrineis a sympathomimetic agent, structurally similar
to ephedrine, used to relieve nasal and sinus congestion and reduce
air-travel-related otalgia in adults.
The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are
found in many over-the-counter preparations either as single-ingredient
preparations, or more commonly in combination with antihistamines and/or
Unlike antihistamines, which modify the systemic histamine-mediated
allergic response, pseudoephedrine only serves to relieve nasal
congestion commonly associated with colds or allergies.
The advantage of oral pseudoephedrine over topical nasal preparations,
such as oxymetazoline, is that it does not cause rebound congestion.
N-methylpseudoephedrineis acts directly on both alpha- and, to a lesser
degree, beta-adrenergic receptors.
Through direct action on alpha-adrenergic receptors in the mucosa of the
respiratory tract, pseudoephedrine produces vasoconstriction.
Pseudoephedrine relaxes bronchial smooth muscle by stimulating
Like ephedrine, pseudoephedrine releasing norepinephrine from its
storage sites, an indirect effect.
Notification: These chemicals are designated as those that are used
in the manufacture of the controlled substances and are important to
the manufacture of the substances. For any (Control Substance)
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