Product Name :
PANTOPRAZOLE SODIUM SALT
Sodium-[5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyri - dinyl)-methyl]-sulfinyl]-1H-benzimidazolide
Formula Weight :
is a substituted benzimidazole proton-pump inhibitor (PPI) that
suppresses gastric acid secretion by inhibiting the gastric (H+,K+)-ATPase
enzyme pump. Pantoprazole Sodium forms a covalent bond to two sites of
the (H+,K+)-ATPase enzyme system at the secretory surface of the gastric
parietal cell; this binding results in antisecretory effects that
persists for more than 24 hours. A significant increase in gastric pH
and decrease in basal acid output follow oral and IV administration of
Pantoprazole Sodium. Pantoprazole Sodium does not antagonize H2 or
Most studies report that gastric acid suppression is dose-related
following IV and oral administration of Pantoprazole Sodium, resulting
in inhibition of both basal and stimulated gastric acid secretion
(irrespective of the stimulus).
Significant in vitro activity against Helicobacter pylori (H. Pylori)
has been demonstrated for Pantoprazole Sodium.
Similar to omeprazole and other PPIs, hypergastrinemia can occur during
Pantoprazole Sodium therapy. Although prolonged hypergastrinemia has
been associated with gastric tumors in rats, long-term studies of proton
pump inhibitors do not suggest the development of tumors in humans.
clinically relevant effects of Pantoprazole Sodium on cardiovascular,
respiratory, ophthalmic, or central nervous system function have been
detected. A short-term (2-week) evaluation showed that oral Pantoprazole
Sodium had no effect on endocrine hormones including: cortisol,
testosterone, triiodothyronine (T3), thyroxine (T4), thyroid-stimulating
hormone, thyronine-binding protein, parathyroid hormone, insulin,
glucagon, renin, aldosterone, follicle-stimulating hormone, luteinizing
hormone, prolactin and growth hormone.
Not considered hazardous when handled
under normal conditions with good house keeping.
dry chemical powder or appropriate foam. Water spray.
Unusual fire and
Emits toxic fumes under fire conditions
Special fire fighting procedures:
self-contained breathing apparatus and protective clothing to prevent
contact with the skin and eyes.
safety, mark out contaminated area with signs and prevent unauthorized
access. Turn leaking containers up to prevent further Evaculate area.
Wear self-contained breathing apparatus, rubber boots & heavy rubber
gloves. Sweep-up/absorb in suitable material, place in a container and
hold for disposal. Avoid raising dust. Ventilate area and wash spill
site after pick-up complete.
Handling and Storage:
Store in original container in a cool dark place.
EXPOSURE CONTROL/PERSONAL PROTECTION:
Respiratory protection: required when
dusts are generated.
Immediately change contaminated clothing. Wash hands and face after
working with substance.
to off-white powder
Do not allow product to enter drinking water supplies, waste water or
Dissolve or mix
material with a suitable combustible solvent and incinerate in a
chemical incinerator equipped with an afterburner and scrubber. Material
should be disposed of in keeping with all local and national
legislation. Packaging should be disposed of in keeping with all local
and national legislation. Handle contaminated containers as product.
While the information herein is believed to be reliable, it is furnished
without warranty of any kind. It shall be used only as a guide. We
assume no liabilities from the use of this product or information
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