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BP - British Pharmacopoeia CP - Chinese Pharmacopoeia EP - European Pharmacopoeia JP - Japanese Pharmacopoeia USP - United States Pharmacopoeia
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Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene units and one nitrogen atom. It is a colorless fuming liquid with an odor described as ammoniacal, pepper-likehe name comes from the genus name Piper, which is the Latin word for pepper.Piperidine is a widely used building block and chemical reagent in the synthesis of organic compounds, including pharmaceuticals.

Stability
Stable. Highly flammable. Incompatible with strong oxidizing agents, strong acids, organic acids, water. Vapours may flow along surfaces to a distant source of ignition.

Toxicology
Poison. May be fatal if inhaled or swallowed. Severe irritant. Skin contact may cause severe irritation or burns. Contact with the eyes may lead to permanent damage.

Toxicity data
ORL-RAT LD50 400 mg kg-1
IPR-MUS LD50 50 mg kg-1
SKN-RBT LD50 320 mg kg-1
ORL-MUS LD50 30 mg kg-1
ORL-RBT LD50 145 mg kg-1

Risk phrases
R11 R23 R24 R34. (Note: The risk phrases here are those given by Annex I. Annex I does not specify R22 or R25, but this material is clearly harmful if swallowed so should be treated as though R22 were included.]

Personal protection
Safety glasses, gloves, good ventilation. Remove sources of ignition from the working area.

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene units and one nitrogen atom. It is a colorless fuming liquid with an odor described as ammoniacal, pepper-likethe name comes from the genus name Piper, which is the Latin word for pepper. Piperidine is a widely used building block and chemical reagent in the synthesis of organic compounds, including pharmaceuticals.

a colorless, liquid hydrocarbon, (CH)NH, found in many alkaloids and obtained by reducing pyridine or by treating piperine with alkali: used in making rubber, oils, fuels, etc.

Production
Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum sulfide catalyst.

Uses
Piperidine is used as a solvent and as a base. The same is true for certain derivatives: N-formylpiperidine is a polar aprotic solvent with better hydrocarbon solubility than other amide solvents, and 2,2,6,6-tetramethylpiperidine is highly sterically hindered base, useful because of its low nucleophilicity and high solubility in organic solvents.

Reactions
Piperidine is a widely used secondary amine. It is widely used to convert ketones to enamines
Enamines derived from piperidine can be used in the Stork enamine alkylation reaction.Piperidine can be converted to the chloramine C5H10NCl with calcium hypochlorite. The resulting chloramine undergoes dehydrohalogenation to afford the cyclic imine.

GENERAL DESCRIPTION & APPLICATIONS
Piperidine, hexahydropyridine, is a family of heterocyclic organic compound derived from pyridine through hydrogenation. It has one nitrogen atom in the cycle. It is a clear liquid with pepper-like aroma. It boils at 106 C, soluble in water, alcohol, and ether. The major application of piperidine is for the production of dipiperidinyl dithium tetrasulfide used as a rubber vulcanization accelerator. In pharmaceutical synthesis industry, it is a skeleton in some drugs such as methylphenidate (central nervous system stimulant), budipine (antiparkinsonian drug) raloxifene (selective estrogen receptor modulator), minoxidil (an oral drug to treat high blood pressure). It is used as a special solvent in solid phase synthesis and a protecting group for peptide synthesis. Piperidine derivative compounds are used as intermediate to make crystal derivative of aromatic nitrogen compounds containing nuclear halogen atoms. Ring system compounds with nitrogen which have basic property playing important roles as cyclic component in industrial field such as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts, antioxidants and as a catalyst for silicone esters. They are used in manufacturing pharmaceuticals. Piperidine is listed as a Table II precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.

SPECIFICATION
APPEARANCE : clear to light yellow liquid
PURITY (G.C)  :  99.5% min
COLOR, APHA : 10 max
SPECIFIC GRAVITY: 0.857 - 0.867
MOISTURE : (K.F) 0.1% max
PACKING : 170kgs in drum

Note: These API/ chemicals are designated as those that are used in the manufacture of the controlled substances and are important to the manufacture of the substances. For any (Control Substance) products Import and Export *** subjected to your country government laws /control substance ACT.

Note /Government Notification:  N/A

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