Amlodpine Besylates
Cas No. 111470-99-6.
Chemical Structure :
Identification
Synonyms
Amlodipine besilate;
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-
methyl-1,4-dihydropyridine benzenesulfonate.
Molecular Formula :
C20H25ClN2O5.C6H6O3S
Molecular Weight 567.05 CAS Registry Number 111470-99-6.
Amlodpine Besylates Description
Amlodipine besylate is the besylate
salt of amlodipine, a long-acting calcium channel blocker.
Amlodipine besylate is chemically
described as 3-Ethyl-5-methyl
(±)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate,
monobenzenesulphonate. Its molecular formula is C20
H25 ClN2
O5 ·C6
H6 O3
S, and its structural formula is:
Amlodipine besylate is a white
crystalline powder with a molecular weight of 567.1. It is slightly
soluble in water and sparingly soluble in ethanol. Amlodipine besylate
tablets are formulated as white tablets equivalent to 2.5, 5 and 10 mg
of amlodipine for oral administration. In addition to the active
ingredient, amlodipine besylate, each tablet contains the following
inactive ingredients: colloidal silicon dioxide, dibasic calcium
phosphate anhydrous, magnesium stearate, microcrystalline cellulose,
sodium starch glycolate, and stearic acid.
Amlodipine Besylate Precautions.
General
Since the vasodilation induced by amlodipine is gradual in onset,
acute hypotension has rarely been reported after oral administration.
Nonetheless, caution, as with any other peripheral vasodilator, should
be exercised when administering amlodipine, particularly in patients
with severe aortic stenosis.
Information
Associated with Product :
Dosage
Uses
Side Effects
Interactions
Alfuzosin,
Amlodipine
Besylate,
Aripiprazole,
Atorvastatin
Calcium,
Candesartan
Cilaxetil,
Cefdinir,
Cetirizine
Dihydrochloride,
Ciprofloxacin HCl,
Dextromethorphan
Base,
Diltiazem HCl,
Domperidone Base,
Domperidone Maleate,
Doxazosin Mesylate,
Duloxetine HCl,
Dutasteride,
Enalapril Maleate,
Esomeprazole
Magnesium,
Famotidine,
Fexofenadine HCl,
Fluconazole,
Fluoxetine HCl,
Galantamine HBr,
Ibuprofen
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